Surgical Endocrine Therapy of Late Prostatic Cancer

Abstract

It has been generally accepted that prostatic cancers as well as breast cancers are characterized by their marked hormone-dependency. Conventionally, the therapy of these carcinomatous diseases has been achieved by radical resection, endocrinological management, etc. Recently, a new surgical treatment, called surgical endocrine therapy, has been developed as one method to inhibit the growth of carcinomata by chang a hormonal environment within the living organism.We performed a set of the combined operation of anastomosis between left adrenal vein and colic vein, bilateral castration, and right adrenalectomy in 22 patients with prostatic cancer who had unfavorably lost the chance of radical operation or had metastasis, for the purpose of changing endocrine milieu within the body. Ten of our cases were associated with metastasis of prostatic cancer to the bone. This report deals especially with roentgenologic examinations of the effects of surgical endocrine therapy on the patients with late prostatic cancer additionally followed with osseous metastasis.The results are follows:In the measurement of urinary 17 KS showed a decrease postoperatively. The decrease of the amount of urinary aldosterone was also postoperatively observed but all the values obtained were within the physiological limits.All of cases almost complete improvement of symptome was observed and 5 out of 10 cases with metastasis to bone were demonstrated marked improvement of roentgenological findings.