Abstract
Tension measurements were made on rabbit basilar artery segments to test the direct effect of thiopental on serotonin (5HT)- and norepinephrine (NE)-induced contraction. At concentrations of 3 × 10-5M or greater, thiopental caused relaxation of NE-induced tension. Thiopental doses greater than 3 × 10-4M had a similar relaxing effect on 5HT-induced contraction. However, thiopental doses below 3 × 10-4M demonstrated an unexpected dose-dependent potentiation of the 5HT-induced contraction. (Neurosurgery 17:433-435, 1985)
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