Surgical Complications and Graft Survival in Pediatric Kidney Transplant Recipients Treated With a Steroid-Free Protocol: Experiences From a Danish University Hospital

Abstract

BackgroundThe outcome of pediatric kidney transplantation depends on several factors, among these are the complications, which occur in relation to the surgical procedure. In this study, we present our experience with pediatric kidney transplantation in a steroid-free immunosuppression regimen, from a surgical point of view. MethodsPatient charts of pediatric kidney transplantations in the period 1998–2011 were reviewed. Surgical complications, acute rejection, and patient and graft survivals were recorded. ResultsSixty-one renal transplantations were performed in 58 patients. Thirty patients (49.1%) experienced a surgical complication, of which 11 (18%) required an explorative laparotomy. Overall the five-year Kaplan-Meier patient survival rate was 96.2% and the graft survival rate was 88.6%. Nine patients (14.7%) had an acute rejection episode within the first year after transplantation. No correlation was observed between surgical complications and acute rejection episodes or graft loss. ConclusionsThis study indicated a high incidence of surgical complications among pediatric kidney transplantations when using a steroid-free immunosuppression regimen. Despite this, we observed high overall patient and graft survival, supporting the trend toward steroids avoidance in pediatric kidney transplantation.