Abstract
Currently, surgery for insulinoma is curative in nearly every patient, even those with MEN1, and fu-ture direction seems to be to make it more cosmeti-cally acceptable and less morbid by trying to accomplish the same procedure laparoscopically. Surgery for gastrinoma and nonfunctional NE tu-mors is curative in approximately 50% of patients. Duodenotomy is indicated during surgery for gastri-noma, because it increases tumor detection and cure rate. Patients with MEN1 with gastrinoma remain a challenge. With our current approach in these pa-tients, the cure rate is low, but the long-term survival remains excellent. The role of routine pancreaticoduodenectomy for sporadic and MEN1 NE tumors is currently unclear. It may increase cure rate, but it may also increase morbidity in pa-tients with a low, long-term tumor death rate.
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