Surgery for gastroenteropancreatic neuroendocrine tumors with synchronous liver metastasis

Abstract

Background: Gastroenteropancreatic neuroendocrine tumors (GEP NETs) are most often diagnosed at an advanced stage with synchronous hepatic metastasis. Surgical management strategies for these patients are controversial, with Level I evidence lacking given the rarity of this diagnosis. We therefore used a national database to investigate survival outcomes associated with resection of primary tumor, resection of the liver metastases, or resection of both the primary tumor and liver metastases.