Surgery for Drug-Resistant Epilepsy in Children

Abstract

To the Editor: The study by Dwivedi and colleagues (Oct. 26 issue)1 on the efficacy of surgery in children with drug-resistant epilepsy includes more patients than either of the two previous randomized, controlled trials of epilepsy surgery. Also, it covers the whole pediatric age span and includes diverse surgical procedures.2,3 However, we have a concern related to the report of serious adverse events in 33% of the patients in the surgery group. Usually, major unexpected complications are reported in less than 5% of the patients in studies of epilepsy surgery.4,5 The explanation is probably that expected adverse events (e.g., the .