Abstract
Micellar solutions and microemulsions have been used for the increase in the solubility of a series of arylquinolin-2-ones in water. Using spectrophotometry, the solubilization capacity of systems has been characterized with respect to arylquinolin-2-ones. As micelle-forming compounds nonionic amphiphiles are used, whose application is approved in medicinal and pharmacological practice, namely, Tween 80, Pluronic F127, Brij 35, and Tyloxapol. For comparison typical ionic surfactants are explored as well. It has been demonstrated that micellar solutions of Tween 80 can increase the content of test compounds in water up to 20 times, while microemulsions exhibit a higher effect. It has been found out that the solubilization process of arylquinolin-2-ones is accompanied by a remarkable change of their acid-base properties: the value рKа may increase by 4 units with the transition from the solutions of cationic surfactants to anionic.
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