Surfactant protein-D level as a predictor of prognosis of interstitial lung disease induced by anticancer agents in advanced lung cancer

Abstract

Introduction: Interstitial lung diseases induced by anticancer agents (ILD-AA) are known to be a rare adverse effect of anti-cancer therapy. However, predictive prognostic fibrotic biomarkers of ILD-AA have not been identified in patients with advanced lung cancer (ALC). Aim: To analyze the association between serum fibrotic biomarkers, including KL-6 and surfactant protein D (SP-D), onset and types of ILD-AA by chest high resolution computed tomography (HRCT) findings in ALC patients. Methods: ΔKL-6 and ΔSP-D were defined as the difference between the values of KL-6 and SP-D level at the onset of ILD-AA and their respective values prior to ILD-AA. Then, patients9 data, including ΔKL-6, ΔSP-D, ILD-AA types on chest HRCT, and outcome in ALC patients were retrospectively collected and evaluated. Results: Thirty-five patients diagnosed with ILD-AA at two hospitals were enrolled in this study. Among them, 13 died of ILD-AA. ΔSP-D in the deceased patients was significantly higher than that in the surviving patients (p Conclusion: Our findings suggested only ΔSP-D was significantly associated with ILD-AA outcome and HRCT findings .