Abstract
In current article an easy and selective method is proposed for spectrophotometric estimation of metoclopramide (MCP) in pharmaceutical preparations using cloud point extraction (CPE) procedure. The method involved reaction between MCP with 1-Naphthol in alkali conditions using Triton X-114 to form a stable dark purple dye. The Beer’s law limit in the range 0.34-9 μg mL-1 of MCP with r =0.9959 (n=3) after optimization. The relative standard deviation (RSD) and percentage recoveries were 0.89 %, and (96.99–104.11%) respectively. As well, using surfactant cloud point extraction as a method to extract MCP was reinforced the extinction coefficient(ε) to 1.7333×105L/mol.cm in surfactant-rich phase. The small volume of organic solvent (500mL/sample) provides an environmentally friendly and low-cost preconcentration method. The suggested method was utilized for analyzing of MCP in commercial pharmaceutical injections.
Highlights
Metoclopramide, chemically known as (4-amino-5-chloro-[N]-[2-(diethylamino) ethyl]-2methoxybenzamide) (Fig. 1)
Metoclopramide works by rising the constriction or movements of the intestines and stomach
A 1% (w/v) of sulfamic acid was prepared by dissolving 1 g with water in a 100 volumetric flask. 0.1000 g of 1-Naphthol which obtained from Sigma Aldrich (USA) was dissolved in an appropriate amount of water diluted in 100 ml volumetric flask to obtain a final concentration 1000 μg ml-1 as stock solution
Summary
Because it has a wide application and a great therapeutic in empirical and clinical medicine, spacious researches concentrated on its determination in dose forms and biological fluids. Metoclopramide works by rising the constriction or movements of the intestines and stomach. For patients with gastroesophageal reflux disease (GERD), MCP is utilized to treat stomach burn gastroesophageal reflux disease (GERD) is esophageal commotion from the in reverse flow of gastric acid into the esophagus. It is used for prevention vomiting that happened after the cancer chemotherapy at higher doses [2]
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