Surfaces With Minimal Or Selective Protein Adsorption Interactions As Model Biomedical Polymers

Abstract

The amount, type, conformation and orientation of proteins that adsorb at an interface during the first minutes of blood exposure are felt to dominate the blood compatibility response of that surface. This study attempts to clarify the role protein adsorption plays in blood-materials interactions by utilising model polymer systems which show minimal protein adsorption at physiological ionic strength and pH. One of these surfaces is then derivatised by various means to allow for selective protein interactions. Bloodmaterials investigations can then be studied as a function of protein interactions with this substrate.