Abstract
This work describes the surface modification of 300PEO-PEOT/PBT 55/45 thin films using a medium pressure dielectric barrier discharge system operated in argon, helium, nitrogen or dry air to improve cell-surface interactions of this established biomaterial. The first part of the paper describes the optimization of the plasma processing parameters using water contact angle goniometry. The optimized samples are then characterized for changes in surface topography and surface chemical composition using atomic force microscopy (AFM) and X-ray fluorescence spectroscopy (XPS) respectively. For all plasma treatments, a pronounced increase in surface wettability was observed, of which the extent is dependent on the used plasma discharge gas. Except for dry air, only minor changes in surface topography were noted, while XPS confirmed that the changes in wettability were mainly chemical in nature with the incorporation of 5–10% of extra oxygen as a variety of polar groups. Similarly, for the nitrogen plasma, 3.8% of nitrogen polar groups were additionally incorporated. Human foreskin fibroblast (HFF) in vitro analysis showed that within the first 24 h after cell seeding, the effects on cell-surface interactivity were highly dependent on the used discharge gas, nitrogen plasma treatment being the most efficient. Differences between untreated and plasma-treated samples were less pronounced compared to other biodegradable materials, but a positive influence on cell adhesion and proliferation was still observed.
Highlights
Biodegradable thermoplastics such as polylactic acid (PLA), polycaprolactone (PCL), polyglycolic acid (PGA), polylactic-glycolic acid (PLGA) and poly (3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) are widely used as structural materials in tissue engineering due to their interesting material characteristics such as a high strength to weight ratio, thermal stability, reproducibility, ease of acquisition, biocompatibility and controlled degradation rates [1,2,3,4]
This paper describes the effect of several plasma treatments
This paper describes the effect of several plasma treatments on PEOT/PBT thin films
Summary
Biodegradable thermoplastics such as polylactic acid (PLA), polycaprolactone (PCL), polyglycolic acid (PGA), polylactic-glycolic acid (PLGA) and poly (3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) are widely used as structural materials in tissue engineering due to their interesting material characteristics such as a high strength to weight ratio, thermal stability, reproducibility, ease of acquisition, biocompatibility and controlled degradation rates [1,2,3,4]. Research groups focusing on biomedical applications have been using these materials as such, or exploited them for the fabrication of 3D scaffolds and nanofiber mats [5]. Their applications range from support structures for musculoskeletal tissue regeneration over bone fillers and nerve guides, to dermal implants [6,7]. Many studies have been published describing the successful modification of biodegradable polyesters (PCL, PLA, PLGA, PGA, PHBV) using non-thermal plasma treatments at medium and atmospheric pressure [9,19,20,21,22,23,24,25,26]. The plasma treatment of biodegradable terephthalates remains largely unexplored
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