Abstract
A dissolution pattern that indicates a solvent-mediated phase change is observed when aspirin crystals are dissolved in aqueous media. It is suggested that the phase change is caused by the crystallization of a less soluble form on the crystal surface during dissolution. The kinetic and thermodynamic parameters of the two forms were determined using a rotating disk method of dissolution. An isergonic relation was demonstrated for the phase transformations of aspirin and other pharmaceutical compounds reported in the literature.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
