Surface Tracking of Curcumin Amorphous Solid Dispersions Formulated by Binary Polymers

Abstract

Herein, curcumin amorphous solid dispersions (Cur ASDs) were prepared using binary polymers (Eudragit EPO with polyvinylpyrrolidone K30 [EuD-PVP], Eudragit EPO with hydroxypropyl methylcellulose E50 [EuD-HPMC]) as excipient, and surface tracking of Cur ASDs was mainly addressed. Infrared spectroscopy, in situ Raman imaging spectroscopy, molecular docking modeling, and contact angle measurements were mainly applied to study the molecular interaction and wetting property of Cur ASDs. Cur/EuD-PVP had a lower cumulative release (approximately 15%) than Cur/EuD-HPMC (approximately 48%) because Cur/EuD-HPMC presented carrier-controlled wetting property while Cur/EuD-PVP fitted to a drug-controlled wetting property. The favorable HPMC can be preferred as superior excipient for Cur ASDs compared with binary polymers, which has potential application in food and drug healthcare industry of Cur.