Surface regularity: A new factor for predicting the expansion of intracerebral hemorrhage?

Abstract

BackgroundThe radiology features of CT can be used to predict the development of hemorrhage. Purpose: To explore the relationship between regularity and the expansion of hematoma by using a novel factor: surface regulation. Methods: This is a retrospective study, where 213 patients (71 females, 33.3 %) are retrospectively analyzed. The inclusion criteria are as follows. The diagnosis of spontaneous supratentorial hemorrhage, admission CT scan and a cranial CT scan obtained within 9 h are required, with other potential causes of intracerebral hemorrhage excluded during hospitalization. The exclusion criteria are as follows. Any patients having operative treatment before the cranial CT scan are excluded. Then, they are divided into the hematoma expansion group based on expanded hematoma (relative growth ≥ 33 % or absolute growth ≥ 6 ml) and the non-hematoma expansion group. After other factors are balanced through a 1:2 PS match, 82 samples (31 females, 37.8 %) are modeled to calculate their surface area and volume by using 3D Slicer and their surface regularity [SR=6√πvolume√surfacearea3]. Results: The mean ± SD SR value of Group-HE is calculated to be 0.557 ± 0.131, while that of Group-NHE is calculated to be 0.631 ± 0.101. The effect of surface regulation on the expansion of intracerebral hemorrhage hematoma is found to be statistically significant (OR 0.004, 95 %CI 0.00–0.27, P = 0.011). Conclusions: There is a link between surface regularity and hematoma expansion during the early stages of intracerebral hemorrhage.