Abstract

Surface potential and surface charge sensing techniques have attracted a wide range of research interest in recent decades. With the development and optimization of detection technologies, especially nanosensors, new mechanisms and techniques are emerging. This review discusses various surface potential sensing techniques, including Kelvin probe force microscopy and chemical field-effect transistor sensors for surface potential sensing, nanopore sensors for surface charge sensing, zeta potentiometer and optical detection technologies for zeta potential detection, for applications in material property, metal ion and molecule studies. The mechanisms and optimization methods for each method are discussed and summarized, with the aim of providing a comprehensive overview of different techniques and experimental guidance for applications in surface potential-based detection.

Highlights

  • Surface potential sensing techniques measure the surface charge density over the solid surface or solid–liquid interface

  • In the presence of an electrical double layer (EDL) when immersing solid into liquids, the target chemical or biological inputs are transformed into electrical signals, referred as surface potential or surface charge

  • Surface potential φo has a linear relationship with surface charge density as σ = Cdl φo, where Cdl is the double layer capacitance that is determined by the ionic strength and ionic valence

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Summary

Introduction

Surface potential sensing techniques measure the surface charge density over the solid surface or solid–liquid interface. Surface potential can be modulated by adsorption of target molecules, e.g., chemical concentrations (pH [10,11,12], metal ion concentration [13,14], etc.), biological species (DNA [15,16,17], protein [18], etc.), electrical modulation (reference electrode) and physical movement (flow velocity [19,20]). In other words, those variables that induce potential or charge change can be detected through surface potential or charge measurement.

Direct
Surface Charge Measurement
Nanopores for surface charge detection:
Zeta Potential Measurement
Streaming Potential Measurement
Streaming
Optical
Electrophoretic
Conclusions and Outlook
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