Abstract
Aminothiol modified gold nanowires have been used as vectors for the delivery of plasmidDNA into two different types of mammalian cells: 3T3 and HeLa. It was measured thatpositively charged gold nanowires with a diameter of 200 nm and a length around5 µm were capable of carrying 1 pg of plasmid DNA per nanowire into cells. Compared with othertransfection reagents, the gold nanowires exhibited the highest transfection efficiency whilealmost no cytotoxicity was observed. In addition, it has been shown that individualnanowires can be visualized with sub-micrometer resolution, which may allow the use offunctionalized multi-segment nanowires as local probes for the investigation of themicroenvironment inside cells.
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