Abstract
In this study, a series of poly(lactic-co-glycolic acid) (PLGA) microspheres with different particle sizes for arterial embolization surgery were prepared. The polydopamine (PDA) and polydopamine/polyethyleneimine (PDA/PEI) were respectively coated on the PLGA microspheres as shells, in order to improve the hydrophilicity and dispersibility of PLGA embolization microspheres. After modification, with the introduction of PDA and PEI, many hydrophilic hydroxyl and amine groups appeared on the surface of the PLGA@PDA and PLGA@PDA/PEI microspheres. SEM images showed the morphologies, sizes, and changes of the as-prepared microspheres. Meanwhile, the XPS and FT-IR spectra demonstrated the successful modification of the PDA and PEI. Water contact angles (WCAs) of the PLGA@PDA and PLGA@PDA/PEI microspheres became smaller, indicating a certain improvement in surface hydrophilicity. In addition, the results of in vitro cytotoxicity showed that modification had little effect on the biosafety of the microspheres. The modified PLGA microspheres suggest a promising prospective application in biomedical field, as the modified microspheres can reduce difficulties in embolization surgery.
Highlights
Functional polymeric microspheres, which are often used in chemical catalysis and adsorption, have some special advantages, including a large specific surface area, strong adsorption capacity, surface reaction ability, and ease of modification [1,2], tumor embolization [3,4], information transfer [5], chromatographic separation [6], and biomedicine [7]
This study reported an eco-friendly preparation of biodegradable and biocompatible poly(lactic-co-glycolic acid) (PLGA)@PDA
This study reported an eco-friendly preparation of via biodegradable and biocompatible and PLGA@PDA/PEI
Summary
Functional polymeric microspheres, which are often used in chemical catalysis and adsorption, have some special advantages, including a large specific surface area, strong adsorption capacity, surface reaction ability, and ease of modification [1,2], tumor embolization [3,4], information transfer [5], chromatographic separation [6], and biomedicine [7]. Transcatheter arterial embolization (TAE) was first reported by Yamamoto et al [8] in 1991, which was an effective technique for the insertion of a catheter into a target tissue or organ. When the target tissue is a tumor, the tumor cells in the target area will be ischemic necrosis [9]. Embolization with embolic microspheres after the infusion of anticancer drugs can reduce drug clearance from cancer cells, and induce ischemic necrosis [10]. Biodegradable microspheres [13,14], such as polylactide (PLA) [15], have received wide attention
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