Surface modification of pH-sensitive honokiol nanoparticles based on dopamine coating for targeted therapy of breast cancer

Abstract

At present, there is a higher demand for the efficacy of nanoparticle drugs. It is hoped that more drugs will reach the tumor site and that the drug will be less harmful to other normal cells of the body before reaching the tumor site. Most target research for nanomedicine can achieve better positioning through complex processes, such as synthesis. To overcome these difficulties, such as the complexity of the preparation method and lack of good targeting, we used simple polydopamine (PDA) as a pH-sensitive targeting anchor for nanoparticles (NPs). We successfully conjugated folic acid (FA) to the surface of honokiol (HK) nanoparticles coated with PDA using a typical surface modifier. After preparation into HK-PDA-FA-NPs, we characterized the particle size, potential and transmission electron microscope (TEM). The targeted nanoparticles (HK-PDA-FA-NPs) can be stably present in various physiological media and exhibit pH sensitivity during drug release in vitro. HK-PDA-FA-NPs have better targeting ability to 4T1 cells than HK-NPs. Targeted nanoparticles have a tumor inhibition rate of greater than 80% in vivo, which is significantly higher than ordinary HK-NPs. This experiment shows that surface modification of HK-NPs coated with PDA is a promising preparation method for targeted therapy.