Surface modification of multiwalled carbon nanotubes via surface RAFT copolymerization method and capecitabine-loaded anticancer hydrogel for controlled drug delivery in stomach

Abstract

ABSTRACT In our work, reversible addition-fragmentation chain transfer (RAFT)/carbon nanotube (CNT)/acrylic acid (AA)/acrylamide (AAm) nanocomposite was synthesized by living radical polymerization. The structure and surface morphology of the synthesized RAFT-CNT-Hydrogel nanocomposites were analyzed by FTIR, 1HNMR, SEM, TEM, XRD, and TGA/DTG techniques. The results indicated that PAA/AAm chains grafted with CNT by RAFT polymerization. RAFT-CNT-Hydrogel nanocomposites for drug release investigated in different buffers resulted in a strong pH-sensitive behavior. In total, the obtained hydrogel drug-delivery systems are presented a proper effect versus stomach cancer in vitro and in vivo, and it can be used as candidates for controlled release of anticancer drugs in stomach with exalted remedial agents.