Abstract
Ti is widely used as a material for orthopedic implants. As rapid and effective osseointegration is a key factor for the successful application of implants, biologically inert Ti materials start to show inherent limitations, such as poor surface cell adhesion, bioactivity, and bone-growth-inducing capabilities. Surface modification can be an efficient and effective approach to addressing the biocompatibility, mechanical, and functionality issues of the various Ti implant materials. In this study, we have overviewed more than 140 papers to summarize the recent progress in the surface modification of Ti implants by physical and/or chemical modification approaches, aiming at optimizing their wear resistance, biocompatibility, and antimicrobial properties. As an advanced manufacturing technology for Ti and Ti alloys, additive manufacturing was particularly addressed in this review. We also provide an outlook for future research directions in this field as a contribution to the development of advanced Ti implants for biomedical applications.
Highlights
Materials 2022, 15, 1749. https://Among metals and alloys, Ti and Ti alloys exhibit superior biocompatibility, chemical inertness, and mechanical properties
Bandyopadhyay et al [124] used the electrothermal polarization method to store charges on the TiO2 nanotubes (TNTs) prepared by anodizing the surface of commercial pure (CP) Ti. 5 weeks of in vivo experiments showed that the mineralized bone formation around the implants with polarized TNTs surface increased by about 40% compared with TNTs, proving that
The authors of the present study have used micro-arc oxidation (MAO) to prepare Ag-containing coatings on CP Ti prepared by selective laser melting (SLM), and obtained an innovative, hierarchical porous surface containing both pores of 10 μm and 1 μm (Figure 11a)
Summary
Ti and Ti alloys exhibit superior biocompatibility, chemical inertness, and mechanical properties. The biological activity of Ti-based alloys and their ability to induce bone growth are inadequate, and the rate of osseointegration after implantation in the human body is slow [7]. The dense oxide film that forms on the surface of Ti materials is unfavorable for inducing calcium phosphate deposition in the body [10], causing inadequate biological integration between the surrounding bone tissue and the implant, which would normally be essential to achieve early and firm osseointegration [11]. Suggestions for related future research are proposed, with the aim of providing a reference for further research directions and innovative ideas
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
