Abstract
AbstractBiofouling is a major challenge in the application of textiles, biosensors, and biomedical implants. In the current work, a straightforward method for the solvent‐free polymerization of antifouling dendritic polyglycerol (dPG) from mussel‐inspired dendritic polyglycerol (MI‐dPG) coatings on hydrophilic titanium dioxide (TiO2) and hydrophobic polydimethylsiloxane (PDMS) is reported. Surface characterization is performed by static water contact angle (CA) measurements, X‐ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Significant lower CA values are obtained after dPG grafting from MI‐dPG‐coated TiO2 and MI‐dPG coated PDMS. Furthermore, XPS shows a time‐dependent increase of the CO bond content upon dPG grafting from MI‐dPG‐coated TiO2 and MI‐dPG‐coated PDMS. Analysis of the surface morphology by SEM shows a clear time‐dependent increase in the surface roughness upon dPG grafting from MI‐dPG‐coated TiO2 and MI‐dPG‐coated PDMS. When the viability of two adhesive cell types is studied via LIVE/DEAD staining, a strong reduction in the cell density is observed after the dPG grafting from MI‐dPG‐coated TiO2 and MI‐dPG‐coated PDMS (a decrease of >95% in all cases). The combined results show that biocompatible but highly cell‐repelling surfaces are efficiently constructed via the grafting of dPG from MI‐dPG‐coated TiO2 and MI‐dPG‐coated PDMS.
Highlights
Biofouling is a major challenge in the application of textiles, biosensors, and in marine applications, where it is the biomedical implants
The MI-dendritic polyglycerol (dPG)-coated surfaces were put in a substrate holder in a custom made flask at 110 °C under high vacuum for >10 h (Figure S1, Supporting Information), ensuring that all solvent was removed from the coatings prior to the grafting process
This drying process led to an increase in the CA, when the coatings were compared to mussel-inspired dendritic polyglycerol (MI-dPG) coatings that were dried under atmospheric pressure for one hour at 50 °C (Figure S3 and Table S1, Supporting Information)
Summary
Biofouling is a major challenge in the application of textiles, biosensors, and in marine applications, where it is the biomedical implants. A time- and temperature-dependent decrease of the CA was clearly observed after the grafting of dPG from the MI-dPG-coated substrates (Figure 2A,B; Figure S4 and Table S2, Supporting Information).
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