Abstract
This chapter aims to describe multifarious schemes of detecting bio-molecules by using surface enhanced Raman spectroscopy (SERS)-substrates. At first, current state of knowledge concerning the mechanism of SERS, SERS-active materials and various parameters that influence SERS have been discussed. Classification of SERS substrates, depending on their physical structures, has been reported in the following section. Finally, fabrication methods and recent applications of SERS including sensing, single molecule SERS, and real-world applications for bio-molecular probing have been highlighted.
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