Abstract

In this work, we argue that the SERS technique allows distinguishing between drug-sensitive and drug-resistant strains on the level of resolution of individual mycobacteria. This result is based on the experimental investigations of deactivated M. tuberculosis strains by the Raman spectroscopy in high-wavenumber region. A discussion of drug resistance-related complexity of emerging specific vibrational bands for proteins and lipids forming a cell’s wall is provided.

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