Abstract
Intense SERS spectra from the native and thermally denaturated DNA adsorbed on silver sol in concentration ranges of the order 10 μg ml −1 are reported. Contrary to investigations on a silver electrode, where from the similarity between the SERS spectra of native and denatured DNA a destabilization of DNA (transition from a double stranded structure to a single stranded structure) after adsorption was inferred, the SERS spectra of native DNA on Ag sol. gave no indication of such a change. The SERS waveneumbers were rather similar to those of the “bulk” Raman spectrum of native DNA. Inthis way, the possibility of applying SERS on silver sol to complex molecular structures without destroying them is demonstrated. Excitation profile investigations suggest that the “electromagnetic” enhancement plays a significant role in SERS of nucleic acids on silver sol.
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