Abstract
The electrochemical behavior of isothipendyl hydrochloride (IPH) was investigated at bare and multiwalled-carbon-nanotube modified glassy carbon electrode (MWCNT-GCE). IPH (55 μM) showed two oxidation peaks in Britton-Robinson (BR) buffer of pH 7.0. The oxidation process of IPH was observed to be irreversible over the pH range of 2.5–9.0. The influence of pH, scan rate, and concentration of the drug on anodic peak was studied. A differential pulse voltammetric method with good precision and accuracy was developed for the determination of IPH in pure and biological fluids. The peak current was found to be linearly dependent on the concentration of IPH in the range of 1.25–55 μM. The values of limit of detection and limit of quantification were noticed to be 0.284 and 0.949 μM, respectively.
Highlights
Since the discovery by Iijima [1], carbon nanotube (CNT) including single-walled carbon nanotube (SWCNT) and multiwalled carbon nanotube (MWCNT), has attracted much attention due to its unique structure and extraordinary properties [2]
The MWCNT-glassy carbon electrode (GCE) was first activated in BR buffer of pH 7.0 by cyclic voltammetric sweeps between 0 and 1.4 V till stable cyclic voltammograms were obtained
At MWCNT-GCE, these oxidation peaks appeared at 0.696 V and 0.912 V, respectively, with a considerable enhancement in the peak current
Summary
Since the discovery by Iijima [1], carbon nanotube (CNT) including single-walled carbon nanotube (SWCNT) and multiwalled carbon nanotube (MWCNT), has attracted much attention due to its unique structure and extraordinary properties [2]. It has demonstrated the ability to promote the electrontransfer reactions of electroactive biomolecules [5,6,7] These excellent properties suggest that CNT is a fascinating electrode material, and it is widely used in electrochemistry and electroanalytical chemistry [8,9,10]. Isothipendyl hydrochloride (Figure 1) is a phenothiazine-related drug and has a broad range of clinical applications as antipruritic for local and generalized allergic reactions and radiation sickness [11]. It reduces vascular permeability and significantly reduces secretory activities. We have developed a differential pulse voltammetric method for the determination of IPH in pure and biological samples
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