Abstract

Surface Engineering of Biomaterials

Highlights

  • Dental implants have been generally used as credible and secure treatments for the restoration of function and aesthetics of edentulous patients [1]

  • RhPDGF-BB, and/or recombinant human bone morphogenic protein-2 (BMP-2) (rhBMP-2)-immobilized Hepa/Ti implants were inserted into beagle dogs; implant stability quotients (ISQ), bone mineral densities, bone volumes, osseointegration, and bone formation were assessed by micro CT and histometrically

  • These results indicate that the surfaces of Ti modified by small molecules, such as, Hepa-DOPA, rhPDGF-BB, rhBMP-2, or rhPDGF-BB/rhBMP-2 cannot be differentiated by scanning electron microscopy (SEM)

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Summary

Introduction

Dental implants have been generally used as credible and secure treatments for the restoration of function and aesthetics of edentulous patients [1]. Patients who have insufficient bone quality and quantity, or poor healing and regenerative capacities have been reported to experience unfavorable results after implant treatment [2]. BMP is a well-known growth factor that enhances bone regeneration by inducing the differentiation of mesenchymal stem cells to osteoblasts and promotes biosynthesis of bone matrix by regulating factors that are required for osteoinduction [7,8]. Several studies have reported that rhBMP-2 has no significant effect on bone formation [9,10]. These negative results were suggested to be due to large initial release of rhBMP-2, lack of standardization of the optimal rhBMP-2 concentration, and the use of only one type of growth factor, as natural regeneration process in man involves multiple growth factors [11–14]

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