Abstract
Wounds present serious medical complications and their healing requires strategies that promote angiogenesis, deposition of collagen as well as re-epithelialization of wounds. Currently used conventional wound healing strategies have become less effective due to various issues associated with them. Thus, novel strategies are needed to be developed for early and effective healing of wounds. Metal-organic frameworks (MOFs), formed by linking of metal ions through organic bridging ligands, are highly tunable hybrid materials and have attracted more considerable scientific attention due to their charming and prominent properties, such as abundant pore structures and multiple functionalities. Surface engineering of MOFs with unique ligands can overcome issues associated with conventional wound healing methods, thus resulting in early and effective wound healing. This review has been undertaken to elaborate wound healing, and the use of surface engineered MOFs for effective and rapid wound healing. The process of wound healing will be discussed followed by a detailed review of recent literature for summarizing applications of surface engineered MOFs for wound healing. MOFs wound healing will be discussed in terms of their use as antibacterial agents, therapeutic delivery vehicles, and dressing systems in wound healing.
Highlights
Skin is the largest organ of the human body that protects the body against external threats, such as injury and microbial attack (Xu et al, 2015)
The wound dressing relying on Metal-organic frameworks (MOFs) has speeded up the wound healing in an infected full-thickness skin defect model due to angiogenesis, synergistic antibacterial effects, reduced inflammation, the proliferation of fibroblasts and collagen deposition (Yao et al, 2020). In another most recent study, Han et al (2020) synthesized photosensitive wound dressing hydrogels using MOFs modified with double-bond modified chitosan, Prussian blue, and quaternary ammonium
Novel MOFs based these multi-functional films effectively prevented S. aureus bacteria-derived wound infection (Figure 4) and enhanced the cutaneous wound repair without recurrence by stimulating the formation of blood vessels, epidermis and dermis (Ren et al, 2019). In another similar recent study, Wang et al copper-based MOFs surface modified with chitosan/polyvinyl alcohol fibers as a wound dressing for enhanced antibacterial and wound properties
Summary
Skin is the largest organ of the human body that protects the body against external threats, such as injury and microbial attack (Xu et al, 2015). Skin damage is one of the most common everyday emergencies and could severely affect the health and lives of people, especially when the defect is severe (Admassie et al, 2018). Wounds are usually considered painful injuries of the skin tissue, when dermal layers are cut, punctured, or broken due to external stimulus or damage
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