Abstract
AbstractThere is growing concern in the medical community that silicones, ubiquitous in health care, may exhibit antigenic, immunogenic, and/or adjuvant activity. Sera from women with silicone breast prostheses were assayed by ELISA for humoral immunoreactivity to a variety of common interstitial and cellular components. In decreasing order of frequency, significant IgG avidities were found against silicone surfaces treated with fibronectin–laminin, phospholipids, no treatment, and fibrinogen when compared with sera obtained from healthy, age‐matched, nonimplanted women and a population of nonimplanted women with previously diagnosed autoimmune diseases. Moreover, the sera from approximately 15% of the positive responders were found to react to matrix proteins independent of the siloxane polymer. The data show human antibody production to native macromolecules with antibody avidity being related to molecular conformation. Silicone may function as an adjuvant by inducing changes in the conformation of native molecules. © 1993 John Wiley & Sons, Inc.
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