Abstract
A brand-new class of Jeffamine-modified fluoro-containing polyimide (6FPI-Jx series, where x ranges from 10, 20, and 30 % by weight) was developed in this study. The existing pristine fluoro-containing polyimide (6FPI) is a flexible and high-performance polymer with low surface energy for advanced engineering applications. Although it has been considered a promising biomaterial for its good blood compatibility, it has known to be toxic to normal cells. Here, we modified 6FPI [with –C (CF3)2- group on backbone] with a hydrophilic diamine monomer, Jeffamine, denoted as 6FPI-Jx, where x is the molar percentage of the total diamines. The newly synthesized 6FPI-Jx series was systematically characterized in terms of surface properties included surface texture, chemistry, potential, and charging. Besides, the 6FPI-Jx copolymer exhibited good mechanical and stability as pristine 6FPI. With the addition of Jeffamine (x = 10 %), 6FPI-J10 displayed considerably improved blood and cell compatibility compared to 6FPI, which was explainable as a combined effect of morphological texture and chemical environment of resulting surface. The new class of 6FPI-Jx exhibited excellent solubility toward a number of organic solvents, which rendered the 6FPI-J10 a great potential candidate as a biocompatible coating for implantable medical devices and also for potential therapeutic applications.
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