Abstract
The free energies of adsorption of procaine, lidocaine, and tetracaine at the air-water interface were estimated from plots of surface pressure (π ≤ 5 dynes/cm) against bulk concentration. Their interaction energies with dipalmitoylphosphatidylethanolamine and dipalmitoyl- lecithin monolayers, previously spread at the air-water interface, were estimated from the increase of surface pressure with increasing concentrations of the subphase-injected anesthetic. Free energies of adsorption and the interaction energies were in the order procaine < lidocaine < tetracaine and correlate with relative anesthetic potencies and the blocking of nerve conduction.
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