Sur les variations de quelques activités enzymatiques dans le globule rouge humain, au cours de diverses circonstances physiologiques et pathologiques

Abstract

Variation of some Enzyme Activities in Human Erythrocytes in Various Physiological and Pathological Conditions Statistics based on 30 healthy adults allow a determination of the amount of reduced glutathione and of the activities of the following erythrocytic enzymes: glucose-6-phosphate dehydrogenase, glutathione reductase, fructose-1,6-diphosphate aldolase, pyruvate kinase, lactate dehydrogenase, catalase and acetylcholinesterase. 1. 1.Cord blood erythrocytes (20 subjects) were examined under identical conditions. Significant differences were found which are discussed as a function of the heterogeneity of the two erythrocyte populations on one hand, and on the other, as a function of the differences of capacity to keep the haemoglobin in a reduced state. 2. 2. 13 cases of various types of jaundice in newborn infants were analysed in regard to the activity of their erythrocyte enzymes. In comparison to that of normal newborn children, very little difference was found. 3. 3. 10 cases of anaemia of renal origin yielded erythrocyte enzymes of a very similar activity to those of the normal adult. 4. 4. 2 cases of anaemia, one aplastic, the other regenerative, were examined from the same aspect as the preceding cases. The variations in activity of both glutathione reductase and the enzymes associated with glucose metabolism—treated as a whole—are proposed as a test of the haematopoietic activity of bone marrow.