Supraspinal projections: origins and their terminals in the mouse spinal cord

Abstract

Event Abstract Back to Event Supraspinal projections: origins and their terminals in the mouse spinal cord Huazheng Liang1, 2*, Emma Schofield1 and George Paxinos1, 2 1 Neuroscience Research Australia, Brain Structure and Function Group, Australia 2 The University of New South Wales, School of Medical Sciences, Australia The present study explored the origins of supraspinal projections in the mouse by injecting FG into the cervical cord. The majority of FG labelled cell groups were similar to those found in large mammals. The precuneiform and the epirubrospinal nuclei were found to project to the spinal cord for the first time. Next, we investigated the vestibulospinal projections arising from the lateral vestibular nucleus (LVe). FG labeled neurons at the caudal level of LVe formed two clusters. The boundary between LVe and MVe was tentatively defined. BDA injections into LVe led to the revelation of vestibulospinal fibers mainly in laminae 6-9 with an ipsilateral predominance. In the lumbar and sacral cord, collaterals extended from the ipsilateral to the contralateral side and mainly terminated in laminae 6-8. Next, termination pattern of raphespinal fibers arising from the hindbrain raphe nuclei was studied. These fibers terminate in both the dorsal and ventral horns in addition to lamina 10. There was a shift of fibers in the ventral horn towards the dorsal and lateral part of the gray matter. Fibers from the adjacent gigantocellular reticular nuclei show similar termination pattern as those from the raphe nuclei with slight difference. CLARITY experiments revealed that serotoninergic fibers are present in all laminae and form bundles regularly in a short distance along the rostrocaudal axis in the medial part of the ventral horn and extend towards the lateral motor neuron column. Keywords: Dorsal horn, ventral horn, Supraspinal projection, raphespinal fibers, vestibulospinal fibers Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: YIC06: Young Investigator Colloquium 6 Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Liang H, Schofield E and Paxinos G (2016). Supraspinal projections: origins and their terminals in the mouse spinal cord. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00075 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Aug 2016; Published Online: 11 Aug 2016. * Correspondence: Dr. Huazheng Liang, Neuroscience Research Australia, Brain Structure and Function Group, Randwick, NSW, Australia, h.liang@neura.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Huazheng Liang Emma Schofield George Paxinos Google Huazheng Liang Emma Schofield George Paxinos Google Scholar Huazheng Liang Emma Schofield George Paxinos PubMed Huazheng Liang Emma Schofield George Paxinos Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.