Abstract
In barbiturate anaesthetized cats, tonic descending inhibition of the excitation of lumbar dorsal horn neurones by impulses in unmyelinated primary afferents was measured by reversibly cooling a more cephalic segment. Administered electrophoretically in the substantia gelatinosa and at sites progressively closer to cell bodies, amounts of bicuculline and strychnine adequate to reduce segmental inhibition failed to reduce supraspinal inhibition. Intravenous bicuculline and strychnine also failed to reduce supraspinal inhibition.
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