Abstract
The aim of this study is to assess the effects of different glucocorticoid administration protocols on biomechanical properties of the first lumbar vertebral body in rats. We divided 40 male rats into the following groups: control, dexamethasone (7 mg/week), dexamethasone (0.7 mg/week), methylprednisolone (7 mg/kg/week), methylprednisolone (5 mg/kg twice weekly), dexamethasone (7 mg/kg three times per week), dexamethasone (0.7 mg/kg three times per week, and low-level laser treated rats. Lumbar vertebrae in rats were exposed to the pulsed laser. We conducted a biomechanical test to examine the mechanical properties of vertebral body in rats' lumbar bone. Supraphysiologic glucocorticoid administration protocols did not impair the biomechanical properties of rats' vertebral bodies compared to control and laser-treated rats. Supraphysiologic glucocorticoid administration caused an anabolic effect on the vertebral bodies.
Highlights
Osteoporosis (OP) is a problem which causes bone lost and fractures which leads to severe pain, deformity; the secondary complications, and eventually possibility of death [1]
In particular GC-induced osteoporosis (GIOP) rat models are reported to be relatively resistant to corticosteroid-induced bone damage [8,9,10]
Previous studies have shown the positive effects of level laser therapy (LLLT) both on intact bone and the bone healing process [26]
Summary
Osteoporosis (OP) is a problem which causes bone lost and fractures which leads to severe pain, deformity; the secondary complications, and eventually possibility of death [1]. Histophorphometric parameters and biochemical markers indicate a decrease in bone formation and minimal changes in bone resorption These parameters are less important with regards to OPassociated fractures and investigations in orthopedic surgery. It would reduce bone strength [12,15,21,22] and bone mineral density (BMD) as shown by BMD and other radiologic imaging techniques [11,13,16,19,21,23,24,25] It would cause a decrease in biomarkers in the serum [13,15,16,17, 24,25]. GCs cause decrease in the molecular elements of bones as shown by the molecular biology techniques [14,17,18,20,22,25]
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