Abstract
Current study investigated the formation of binary and ternary inclusion complexes of Irbesartan (IRB) with Hydroxypropyl-β-Cyclodextrin (HP-βCD) as host and l-Arginine (L-Arg) as ternary agent. Inclusion complexes were characterized using solubility, invitro release, DSC and XRD studies. Host-guest interactions were explored by FTIR, 1H NMR and molecular docking studies. Significant enhancement in stability constant and complexation efficiency of HP-βCD was observed in ternary complexes due to the presence of L-Arg. Ternary complexes exhibited greater solubility and dissolution of IRB than binary complexes. Thus, ternary complexation of IRB could offer an innovative strategy for improvement of solubility and dissolution of IRB.
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