Abstract
A supramolecular strategy of switching the self-assembly of cyclic peptide-polymer conjugates using host-guest chemistry is proposed. The formation of tubular supramolecular polymers based on cyclic peptide-polymer conjugates can be controlled by reversibly attaching cucurbit[7]uril onto the cyclic peptide via host-guest interactions.
Highlights
A supramolecular strategy of switching the self-assembly of cyclic peptide–polymer conjugates using host–guest chemistry is proposed
The formation of tubular supramolecular polymers based on cyclic peptide–polymer conjugates can be controlled by reversibly attaching cucurbit[7]uril onto the cyclic peptide via host–guest interactions
As a proof of concept, we designed and synthesized a cyclic peptide conjugated with a water-soluble polymer–poly(ethylene glycol) (PEG), which could form tubular supramolecular polymers in aqueous solution, Scheme 1
Summary
Supramolecular switching of the self-assembly of cyclic peptide–polymer conjugates via host–guest chemistry† A supramolecular strategy of switching the self-assembly of cyclic peptide–polymer conjugates using host–guest chemistry is proposed. The formation of tubular supramolecular polymers based on cyclic peptide–polymer conjugates can be controlled by reversibly attaching cucurbit[7]uril onto the cyclic peptide via host–guest interactions.
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