Supramolecular organization and enzyme-effector properties of double coordination salts with malatostannate/germanate(IV) anions and Fe(II), Co(II), Ni(II), Cu(II) 1,10-phenanthroline cations

Abstract

Article reports synthesis, structure and characteristics (X-Ray, Elemental, IR-, Hirshfeld surface analysis) of novel supramolecular salts with 1,10-phenanthroline 3d-metals cations and similar malatostannate/germanate(IV) anions [Fe(phen)3]2[{Sn(HMal)2(Mal)}Cl]·14H2O (1), [Co(phen)3]2[{Sn(HMal)2(Mal)}Cl]·14H2O (2), [Ni(phen)3]2[{Sn(HMal)2(Mal)}Cl]·14H2O (3), [Cu(phen)3]2[{Sn(HMal)2(Mal)}Cl]·10H2O (4), [Co(phen)3]2[Ge(HMal)(Mal)2]·14H2O (5). It was established that malate anions [Sn(HMal)2(Mal)]3- (1–4) and [Ge(HMal)(Mal)2]4− (5) contain same bidentate HMal2− and Mal3− forms and differ only with their number. The Sn/Ge atoms are six-coordinated and their polyhedrons are distorted octahedrons. The specific feature of the compounds 1–4 is the presence of the additional Cl−anion, that compensates charge of the two [M(phen)3]2+cations and additionally connects them between each other. Novel supramolecular salts showed themselves as efficient enzyme effectors for α-L-rhamnosidase of Cryptococcus albidus because of their structural features (cations as electrophilic hydrophobic and anions as nucleophilic hydrophilic agents) and nature of metal in their composition. Comparing the compounds 1–5 with the previously obtained tartratogermantes/stannates(IV) revealed that difference in the number of hydroxylic groups in the composition of ligands brings a significant change to the structure of the complex anion.