Abstract
Cyclodextrins (CDs) have been extensively studied as drug delivery carriers through host–guest interactions. CD-based poly(pseudo)rotaxanes, which are composed of one or more CD rings threading on the polymer chain with or without bulky groups (or stoppers), have attracted great interest in the development of supramolecular biomaterials. Poly(ethylene oxide) (PEO) is a water-soluble, biocompatible polymer. Depending on the molecular weight, PEO can be used as a plasticizer or as a toughening agent. Moreover, the hydrogels of PEO are also extensively studied because of their outstanding characteristics in biological drug delivery systems. These biomaterials based on CD and PEO for controlled drug delivery have received increasing attention in recent years. In this review, we summarize the recent progress in supramolecular architectures, focusing on poly(pseudo)rotaxanes, vesicles and supramolecular hydrogels based on CDs and PEO for drug delivery. Particular focus will be devoted to the structures and properties of supramolecular copolymers based on these materials as well as their use for the design and synthesis of supramolecular hydrogels. Moreover, the various applications of drug delivery techniques such as drug absorption, controlled release and drug targeting based CD/PEO supramolecular complexes, are also discussed.
Highlights
Some tissues and biological barriers [1,2,3,4,5,6,7] within our bodies prevent foreign materials, such as drugs, pollutants, and viruses, from accessing the important organs [8,9]
We summarize the recent progress regarding the drug delivery applications ofsupramolecular architectures based on CD and Poly(ethylene oxide) (PEO) from 2008 to present
We have described the recent advances in supramolecular architectures based on CDs and poly(ethylene oxide) (PEO) for drug delivery
Summary
Some tissues and biological barriers [1,2,3,4,5,6,7] within our bodies prevent foreign materials, such as drugs, pollutants, and viruses, from accessing the important organs [8,9]. The structures of CD derivatives influenced the properties of the inclusion complexes (ICs) This was demonstrated by a physico-chemical study for the copolymer based on PEO-b-PPO-b-PEO and CDs [48]. The solvent-sensitive or thermoresponsive properties, as well as the PPRs or PRs as inclusions consisting of either one or two threaded chains characteristic crystal structure, and the influence of CD and their derivatives, have pushed the applications of this kind of novel biomaterial for drug delivery. The ability of PF127 to displace guest molecules from the CD cavities can effectively modify the release properties of the aqueous drug–CDs complexes, which would provide valuable opportunities for new drug delivery systems based on the formation of polypseudorotaxanes.
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