Supramolecular Linear Conglomerates Formed by β-Cyclodextrin Dimers and Sodium Deoxycholate

Abstract

The formation of supramolecular structures by the complexation of two bile salts--sodium cholate (NaC) and sodium deoxycholate (NaDC)--with four new head-to-head g -cyclodextrin dimers was studied by NMR techniques. All dimers form 1:2 (dimer:bile salt) stoichiometry complexes with NaC. With NaDC, linear supramolecular conglomerates of an n : n stoichiometry were obtained for all dimers. ROESY spectra confirmed the presence of electrostatic interactions when a protonated amino group is present in the linking group. The dependence of the pseudo-equilibrium constants with the electrostatic interactions and steric hindrance is discussed.