Supramolecular Hybrid Assemblies Based on Cyclodextrin with Stimuli‐Responsiveness: Recent Advances

Abstract

Supramolecular hybrid assemblies based on cyclodextrin are a recently investigated research area ranging from chemistry to material science. In the field of nanomaterials for treatment of damaging diseases, recent developments concern single molecule- to multi-stimuli-driven supramolecular cyclodextrin assemblies ranging from single- to multimodal therapeutic and diagnostic effects. Cyclodextrin assemblies take shape by self- or inter-module assembly of cyclodextrins, drugs, polymeric and/or inorganic components. Their features for biomedical performance can be generated by physicochemical inducement, including light, pH, ionic strength and temperature changes, redox, enzyme, magnetic or sono-chemical cues. In this chapter, we will focus on selected examples of supramolecular hybrid assemblies based on cyclodextrin (inorganic nanohybrids, phototherapeutic complexes, magnetic assemblies, and supramolecular hydrogels), mainly responsive to light and magnetic field stimuli but also toward temperature, pH, redox, and ionic strength changes. In perspective, the smart constructs here described, if opportunely regularized, can find application in the design of nano/micro devices for precision treatments or in emerging therapies which target intra-organ inflammation and tumors.