Supramolecular frameworks formed via hydrogen bonding and non-covalent interactions and interaction energy calculations of solvent coordinated cis-dioxomolybdenum(VI) complexes derived from ONO donor aroylhydrazone: Cytotoxicity studies

Abstract

A tridentate ONO donor aroylhydrazone, 3,5-diiodosalicylaldehyde-4-methoxybenzoylhydrazone (H2SMB) and four cis-MoO2 complexes [MoO2(SMB)(DMF)] (1), [MoO2(SMB)(DMSO)] (2), [MoO2(SMB)(py)] (3) and [MoO2(SMB)(3-pic)] (4) which vary the solvents/heterocyclic bases in the sixth coordination position have been synthesised. The compounds were characterized by different physico-chemical methods. The single crystal X-ray diffraction studies unambiguously confirm the molecular structures. In the complexes 1, 2, 3 and 4, the octahedral geometry around the Mo(VI) central atom is satisfied by ONO donor atoms and two oxo oxygens, the sixth coordination site is occupied by oxygen/nitrogen atoms of solvent molecules. The supramolecular architectures generated by various hydrogen bonding and non-bonding interactions were investigated. The interaction energy calculations reveal dominance of dispersion energy component over other components. The aroylhydrazone was screened for antioxidant study using DPPH assay. The in vitro cytotoxicity of Mo(VI) complexes was evaluated against lymphoma ascites cell line as well as against normal cell and compared to hydrazone and cyclophosphamide.