Supramolecular β-cyclodextrin as a Biodegradable and Reusable Catalyst Promoted Environmentally Friendly Synthesis of Pyrano[2,3-d]pyrimidine Scaffolds via Tandem Knoevenagel–Michael–Cyclocondensation Reaction in Aqueous Media

Abstract

The catalytic activity of supramolecular β-cyclodextrin as a biodegradable and reusable catalyst was studied for the synthesis of pyrano[2,3-d]pyrimidine scaffolds in aqueous media. This green and eco-safe domino approach revealed simplicity, use of biodegradable and highly efficient catalyst, avoidance of toxic organic solvents, versatility and high stability of the catalyst combined with excellent yields, easy work-up procedures with no necessity of chromatographic purification steps, the reusability of the catalyst and being in agreement with the green chemistry protocols, and time-saving aspects of the reaction suggest that this method presents real alternatives over conventional reaction protocols.