SUPRAMOLECULAR ANTIHELMINTHIC COMPLEX ALTRIK-EXTRA FOR THE TREATMENT AND PREVENTION OF MAJOR ANIMAL HELMINTHOSES

Abstract

Animal helminthiasis is widespread in Russia and other countries, which cause great economic damage to animal husbandry due to a decrease in all types of productivity, lagging in the growth and development of young animals and the death of animals, especially young animals. As a result of joint work of employees of the Institute of Organoelement compounds N.A. Nesmeyanova (INEOS RAS, Moscow) and VNIIP K.I. Scriabina, using mechanochemical nanotechnology, developed an innovative drug in the form of a supramolecular complex based on the substances albendazole-extra and triclabendazole and water-soluble low-molecular polyvinylpyrrallidone (PVP-17) in the ratio ABZ-extra: TKB:PVP-17=1:1:8, where 10.0 mg of the drug contains 1.0 mg of ABZ and TKB, which is a white powder with a particle size of 0.1–10 microns. The essence of this work was the development of a complex drug that could effectively and without negative consequences affect the listed 3 classes of helminths that parasitize in mixed form in animals, in order to reduce the laborious work on prevention and treatment. The supramolecular complex of albendazole-extra and triclabendazole, named by us "Altrik-Extra", is intended for the treatment of animals with acute and chronic form of fasciosis, nematodoses of the digestive and pulmonary tracts, and it also has cestodocidal activity, which is important for deworming animals in the summer, when animals are parasitized by helminths of the listed classes in mixed form.