Abstract
This study investigated the effects of dexamethasone (1 mg orally) on the function of the hypothalamic-pituitary-thyroid (HPT) axis. We determined pre- and post-dexamethasone thyroid-secreting hormone (TSH), free thyroxine (FT 4), free triiodothyronine (FT 3), reverse T 3 and cortisol levels in 61 depressed inpatients. Dexamethasone had a pronounced suppressive effect on basal TSH and FT 3 levels. It had a significant stimulating effect on rT 3 levels. No differences were found between melancholic and minor depressives in the effects of dexamethasone on basal TSH, FT 3 and rT 3. Cortisol non-suppressors were characterized by less suppression of basal TSH values.
Published Version
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