Abstract
To study the factors affecting tolerance induction in different subpopulations of lymphocytes at different stages of their maturation, a system involving the neonatal induction of tolerance to bovine serum albumin (BSA) in inbred rats was established. It was found that thymocytes readily became tolerant of BSA either in the presence or absence of the thymus itself, whereas peripheral thymus-derived (T) and bone marrow-derived (B) cells failed to become tolerant in the absence of the thymus. Adult normal rats could not be induced to become tolerant of BSA, though they did become partially tolerant of ovalbumin. The possibility that the thymus or some subpopulation of T cells has a suppressor function which wanes in adult life is suggested. Any such cell apparently is not well represented in either thymocyte or non-adherent peripheral blood lymphocyte populations.
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