Abstract
Alcohol is usually consumed with meals, but chronic consumption is a leading cause of alcoholic liver diseases. We investigated if shiitake extracts with a high lentinic acid content (Shiitake-H) and without lentinic acid (Shiitake-N) could suppress the elevation in plasma ethanol concentrations by accelerating ethanol metabolism and preventing ethanol absorption from the gut. Shiitake-H and Shiitake-N suppressed the elevation in concentrations of ethanol and acetaldehyde in plasma, and promoted the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the liver. However, these effects of Shiitake-H were more prominent than those of Shiitake-N. Furthermore, Shitake-H promoted ADH and ALDH activities in the stomach. We also examined the change in plasma ethanol concentration by injecting Shiitake-H or Shiitake-N into the ligated loop of the stomach or jejunum together with an ethanol solution. Shiitake-H suppressed the absorption of ethanol from the stomach and jejunum. In conclusion, Shiitake-H accelerates ethanol metabolism in the stomach and liver and inhibits ethanol absorption in the stomach and jejunum indicating that lentinic acid is a functional component in shiitake.
Highlights
The moderate intake of alcohol stimulates our appetite and has favorable effects on our health.excessive intake sometimes leads to various diseases
Ethanol is converted to acetaldehyde, its primary metabolite, by alcohol dehydrogenase (ADH), and further to acetic acid by acetaldehyde dehydrogenase (ALDH)
As acetaldehyde is largely responsible for alcohol-related symptoms in addition to mutagenic and carcinogenic lesions, its rapid metabolism to acetic acid is important to reduce the risk of health damage
Summary
The moderate intake of alcohol stimulates our appetite and has favorable effects on our health. Excessive intake sometimes leads to various diseases. Ethanol is converted to acetaldehyde, its primary metabolite, by alcohol dehydrogenase (ADH), and further to acetic acid by acetaldehyde dehydrogenase (ALDH). As acetaldehyde is largely responsible for alcohol-related symptoms in addition to mutagenic and carcinogenic lesions, its rapid metabolism to acetic acid is important to reduce the risk of health damage. Half of Asian people are susceptible to acute alcohol intoxication due to a lack of ALDH2 [5], one of the enzymes for metabolizing acetaldehyde to acetic acid
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
