Abstract
Abstract Swiss-Webster mice injected intravenously with interferon preparations 2 days before primary or secondary immunization with sheep erythrocytes showed a significant suppression of their hemolysin and agglutinin responses as measured in microtiter assays. Interferon treatment in vivo also inhibited DNA synthesis induced in mouse lymphocytes studied in vitro by concanavalin A, phytohemagglutinin, and lipopolysaccharide. In addition, it suppressed the in vitro primary and secondary response to sheep erythrocytes. It is possible that this inhibition of the immune response by interferon is significant in the immunosuppression observed during viral infection or after administration of nonspecific mitogens, or perhaps even in the control of the normal immune response.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
