Abstract
Transcription of polyoma, SV40 and Moloney leukemia virus genomes is suppressed in undifferentiated teratocarcinoma cells. This suppression is due to a celluar factor (or factors) present in the stem cells of the early developmental stage of embryogenesis. Inhibition of transcription involves sequence specific interaction of the factor to viral enhancers. The repressor-like factor thus revealed from the study of virus infection of undifferentiated stem cells, seems to play an important role in the maintenance of the undifferentiated state of cells. A variety of host cellular genes may be regulated by this factor.
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