Suppression of ovarian oxytocin secretion after intra-luteal administration of the arachidonate 5-lipoxygenase inhibitor BWA4C in the ewe

Abstract

The effect of an intra-luteal injection of the 5-lipoxygenase (5-LO) inhibitor BWA4C (2 mg in 50 μ1 dmso) on the secretion of oxytocin (OT) from the corpus luteum in response to a close-arterial infusion of prostaglandin (PG)-F 2α (5 ng mint) was examined in anaesthetised sheep. Within 30 minutes of administration both basal (pre-infusion) and PGF 2 α stimulated OT release into the posterior vena cava were significantly (P<0·01) reduced. These results are consistent with the proposition that 5-LO products of arachidonic acid may modulate OT secretion from the ovine corpus luteum.