Abstract
The effect of arachidonic acid on the A current ( I A) has been studied in dissociated bullfrog neurons under whole-cell voltage-damp conditions. Arachidonic acid reduced I A in a dose-dependent and reversible manner without a shift in the prepulse inactivation voltage-current relation. 1.75 μM inhibited i A by 50%, and higher concentrations caused a total suppression. In addition, arachidonic add increased the M-current ( I M), a different potassium current that does not inactivate. Neither indomethacin nor nordihydroguaiaretic acid, cyclooxygenase and lipoxygenase inhibitors respectively, prevented I A reduction. In contrast, nordihydroguaiaretic acid prevented I M enhancement. Eicosatetraynoic acid, an arachidonic acid analog that cannot be metabolized, also reduced I A. These results suggest that arachidonic acid metabolism is not required to suppress I A
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